The Integration of GIS-Based Information Mapping into an Ethnohistorical Seminar

A GIS-based project constructing a digital, interactive map of the Native American experience served as a useful tool for creating student ownership of the learning process in an undergraduate seminar on the indigenous cultures of the Americas. Student researchers collected primary documents, linguistic data, maps and other images, bibliographic resources, links to relevant web resources, and brief encyclopedia-style essays. The information was then integrated into a GIS dataset for use with ArcMap software, with the ultimate goal of compiling a digital resource that would be refined and expanded by future waves of students in this course

Containerless low gravity processing of glass forming and immiscible alloys

Under normal one-g conditions immiscible alloys segregate extensively during solidification due to sedimentation of the more dense of the immiscible liquid phases. Immiscible (hypermonotectic) gold-rhodium alloys were processed in the 100 meter drop tube under low gravity, containerless conditions to determine the feasibility of producing dispersed structures. Three alloy compositions were utilized. Alloys containing 10 percent by volume of the gold-rich hypermonotectic phase exhibited a tendency for the gold-rich liquid to wet the outer surface of the samples. This wetting tendency led to extensive segregation in several cases. Alloys containing 80 and 90 percent by volume of the gold-rich phase possessed completely different microstructures from the 10 percent samples when processed under low-g, containerless conditions. Several samples exhibited microstructures consisting of well dispersed 2 to 3 microns diameter rhodium-rich spheres in a gold-rich matrix

The Violation of Style: Englishness in Edward St Aubyn’s Patrick Melrose Novels

This article explores the meaningfulness of ‘style’ as a critical concept in contemporary English literary studies. Despite appearing to have fallen out of fashion with the rise of theory in the 1970s, style remains closely linked to canons of historical thought. The article reflects upon how the vicissitudes of English literary style emerge from the historical conditions of upper class Englishness, particularly its ridiculing of Enlightenment abstraction. Through a close reading of Edward St Aubyn's Patrick Melrose novels (1992–2011), it is argued that style remains an ‘English’ inheritance, but that it has been infiltrated by the legacies of Nietzschean and psychoanalytic conceptions of modern subjectivity, and by the voices of literary modernism. The novel sequence disquietingly suggests that St Aubyn's protagonist, Patrick Melrose, was inducted into style when raped as a child by his father. Shorn of its aristocratic confidence, style appears by turns coercive and vulnerably self-conflicted. Violation bequeaths to Patrick a pointed and painful subject position in narrative and in language, as his subsequent addiction to baroque similes reveals; it also re-connects the novels’ celebrated literary elegance to a moment of constitutional violence

Introduction: The Contemporary Problem of Style

This essay sets the parameters of this special issue on the contemporary problem of style. Noting that the critical term style has returned to discursive prominence in recent years, the introduction explores the peculiarity of its status in literary studies. Asking how style underlies our critical practice today, it tracks the partially conflicting genealogies of style and the variety of its disciplinary relations. It explores the problem of style now: in its modernist inheritances; its association to class and nationality, especially Englishness; its reconfiguration through world Englishes and the global novel; its coupling with new aestheticism and new formalism; its recasting as a problem of receptivity and attachment in the era of ‘post-critique’; its intimate connection to shame, affect and embodiment (given especial impetus by critical race theory and sexuality studies); and its persistent association with subcultures and the scandalous pleasures of ‘lifestyle’

Knock-in of Human BACE1 Cleaves Murine APP and Reiterates Alzheimer-like PhenoTypes

Footnotes We thank Roemex and the College for Life Science and Medicine at the University of Aberdeen for their generous support. The authors declare no competing financial interests.Peer reviewedPublisher PD

Between and within laboratory reliability of mouse behaviour recorded in home-cage and open-field

Peer reviewedPostprin

The Hubble Constant

Considerable progress has been made in determining the Hubble constant over the past two decades. We discuss the cosmological context and importance of an accurate measurement of the Hubble constant, and focus on six high-precision distance-determination methods: Cepheids, tip of the red giant branch, maser galaxies, surface brightness fluctuations, the Tully-Fisher relation and Type Ia supernovae. We discuss in detail known systematic errors in the measurement of galaxy distances and how to minimize them. Our best current estimate of the Hubble constant is 73 +/-2 (random) +/-4 (systematic) km/s/Mpc. The importance of improved accuracy in the Hubble constant will increase over the next decade with new missions and experiments designed to increase the precision in other cosmological parameters. We outline the steps that will be required to deliver a value of the Hubble constant to 2% systematic uncertainty and discuss the constraints on other cosmological parameters that will then be possible with such accuracy.Comment: To be published in Annual Reviews of Astronomy and Astrophysics, Vol. 48, 2010, consisting of 79 pages, 13 figures, 2 table

A brief haemophilia pain coping questionnaire

Development and psychometric assessment of a questionnaire measuring pain coping for people with haemophiliaPain coping strategies are important influences on outcomes among people with painful chronic conditions. The pain coping strategies questionnaire (CSQ) was reviously adapted for sickle cell disease and haemophilia, but those versions have 80 items, and a briefer version with similar psychometric properties would facilitate research on pain coping. The full-length haemophilia-adapted CSQ, plus measures of pain frequency and intensity, pain acceptance, pain readiness to change, and health-related quality of life were completed by 190 men with haemophilia. Items were selected for a 27-item short form, which was completed 6 months later by 129 (68%) participants. Factor structure, reliability and concurrent validity were the same in the long and short forms. For the short form, internal reliabilities of the three composite scales were 0.86 for negative thoughts, 0.80 for active coping and 0.76 for passive adherence. Test–retest reliabilities were 0.73 for negative thoughts, 0.70 for active coping and 0.64 for passive adherence. Negative thoughts were associated with less readiness to change, less acceptance of pain and more impaired health-related quality of life, whereas active coping was associated with greater readiness to change and more acceptance of pain. The short form is a convenient brief measure of pain coping with good psychometric properties, and could be used to extend research on pain coping in haemophilia